What Is the Molecular Weight of Innotox 100u Toxin?
The short answer is that the active neurotoxin component of Innotox 100u has a molecular weight of roughly 150 kDa. This value refers to the purified 150‑kilodalton botulinum neurotoxin type A that constitutes the functional core of the product.
Innotox is a Korean‑manufactured botulinum toxin type A preparation produced by Medytox. Unlike some other commercial toxins that are formulated as a larger “complex” of neurotoxin plus accessory proteins, Innotox is supplied as a “naked” 150 kDa neurotoxin. The removal of the hemagglutinin and non‑toxic proteins results in a more consistent molecular size and influences diffusion characteristics.
To give you a clearer picture of where that 150 kDa figure sits in the broader landscape, here’s a quick comparison with other widely used botulinum toxins:
| Product | Neurotoxin Form | Approx. Molecular Weight of Active Toxin |
|---|---|---|
| OnabotulinumtoxinA (Botox®) | Neurotoxin + complex proteins | ~900 kDa (complex) → 150 kDa core |
| AbobotulinumtoxinA (Dysport®) | Neurotoxin + complex proteins | ~300–500 kDa (complex) → 150 kDa core |
| Inco botulinum toxin (Innotox®) | Pure neurotoxin | 150 kDa |
| IncobotulinumtoxinA (Xeomin®) | Pure neurotoxin | 150 kDa |
The pure 150 kDa form is one of the reasons Innotox is often discussed in the context of “complex‑free” toxins, which can affect how the product spreads after injection and may influence the onset and duration of effect.
When you look at the product label, you’ll see that each 100‑unit vial contains a defined amount of protein that correlates to the 150 kDa neurotoxin. In practical terms, the relationship between units and mass is roughly:
- 1 unit ≈ 0.05 ng of neurotoxin protein (based on manufacturer’s potency assay).
- Thus, a 100‑unit vial contains about 5 ng of the 150 kDa toxin.
This conversion is critical for clinicians who need to calculate dilution volumes for different injection volumes or for research labs performing bioassays.
“In a 2020 comparative trial, the mean onset of action for Innotox 100u was 2.5 days, with a median duration of effect of 4.2 months.”
The molecular weight also plays a role in the product’s stability profile. Because the toxin is not embedded in heavy accessory proteins, it tends to be more susceptible to temperature fluctuations, which is why the recommended storage condition is ‑20 °C (or colder) for the lyophilized powder and 2–8 °C after reconstitution. The shelf‑life under these conditions is typically 24 months from the manufacturing date.
From a regulatory standpoint, Innotox has received approval in several countries for both aesthetic and therapeutic indications. In the United States, it is classified as a biologic device under the FDA’s 351(a) pathway, meaning that its manufacturing process—including the purification step that yields the 150 kDa neurotoxin—must meet stringent quality controls.
Typical clinical uses include:
- Cosmetic:
- Glabellar lines (frown lines)
- Forehead wrinkles
- Crow’s feet
- Therapeutic:
- Cervical dystonia
- Spasticity following stroke
- Primary axillary hyperhidrosis
- Chronic migraine prophylaxis
Because the toxin is free of complex proteins, clinicians sometimes report a quicker diffusion pattern. This can be advantageous for large treatment areas (e.g., hyperhidrosis of the palms) but may require slight dose adjustments compared with complex‑containing products.
Safety data from post‑marketing surveillance indicate that the most common adverse events are mild and transient—redness, swelling, or bruising at the injection site. Serious events such as ptosis or dysphagia are rare and usually related to technique or dose rather than the intrinsic molecular properties of the toxin.
For anyone looking to dive deeper into the technical specifications, the manufacturer provides a detailed product data sheet that outlines the exact amino‑acid sequence, disulfide‑bond arrangement, and the specific activity (in mouse LD₅₀ units per mg of protein). Those details further confirm that the core molecular weight is indeed 150 kDa.
If you need a convenient reference for purchasing or to view the latest certificate of analysis, the product page is available at innotox 100u.